HIGH-DOSE VITAMIN C ON SEPSIS: PROTOCOL OF A PROSPECTIVE, MULTI-CENTERED, DOUBLE-BLINDED, RANDOMIZED, AND PLACEBO-CONTROLLED SUPERIORITY STUDY

High-dose vitamin C on sepsis: Protocol of a prospective, multi-centered, double-blinded, randomized, and placebo-controlled superiority study

BackgroundSepsis is an inflammatory syndrome with life-threatening organ dysfunction and high mortality.In the recent 10 years, high-dose intravenous injection of vitamin C, the first-line antioxidant of humans, has received highlighted attention in the field of critical care.The Pillows study aims to examine the efficacy and safety of high-dose in

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Regions of the Cf-9B Disease Resistance Protein Able to Cause Spontaneous Necrosis in Nicotiana benthamiana Lie Within the Region Controlling Pathogen Recognition in Tomato

The tomato Cf-9 and Cf-9B genes both confer resistance to the leaf mold fungus Cladosporium fulvum but only Cf-9 confers seedling resistance and recognizes the avirulence (Avr) protein Avr9 produced by C.fulvum.Using domain swaps, leucine-rich repeats (LRR) 5 to 15 of Cf-9 were shown to be required for Cf-9-specific resistance to C.fulvum in tomato

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Association of suicidal behavior with exposure to suicide and suicide attempt: A systematic review and multilevel meta-analysis.

BackgroundExposure to suicidal behavior may be associated with increased risk of suicide, suicide attempt, and suicidal ideation and is a significant public health problem.However, evidence to date has not reliably distinguished between exposure to suicide versus suicide PET ESSENTIALS FOR DOGS attempt, nor whether the risk differs across suicide-r

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